BioPharm Vapor Compression Distillation

Vapor Compression Distillation

Vapor Compression Distillers produce consistent, reliable, high-purity Water for Injection (WFI) for parenteral solutions, cell culture growth, vaccines and other critical applications.
Aqua-Chem manufactures a variety of standard models of Vapor Compression Distillers for the pharmaceutical industry. Aqua-Chem’s horizontal spray film design is designed to recycle latent heat energy, which makes our distillers more energy efficient. The basis of our innovative design delivers reduced energy consumption and has less stringent feedwater requirements when compared to other distillation processes like multiple-effect systems, making Aqua-Chem Vapor Compression Distillers a popular and sustainable choice for water purification.
All components are accessible from floor-level, with the compressor and pump convenient located at the edge of the skid for easy serviceability. Aqua-Chem utilizes low-speed compressor technology, which results in cooler bearing temperatures and means less downtime for expensive motor repair and replacement.   Our standard validation package is specifically designed to help your team with commissioning activities.

CAPACITY: 250 gph up to 9000 gph

SYSTEMS: 4 Standard BioPharm units, but custom units available.


  • Standard materials used are 316L stainless steel and product contact surfaces are 15-25 RA finish
  • Sanitary valves, instruments, pumps and piping
  • Operation is fully automatic requiring minimal operator input
  • Deaerator removes carbon dioxide, oxygen and other noncondensable gases from the feedwater and distillate
  • Small overall dimensions allow unit to be shipped in standard shipping containers & fit through standard industrial building hallways and doorways


  • Aqua-Chem patented Spray-Film® vapor compression distillation units produce consistent, reliable, high-purity water regardless of feedwater quality fluctuations.
  • Distillation is the only process that removes all known viruses or bacteria 100 percent of the time.
  • The Aqua-Chem patented Spray-Film® evaporator design provides improved wetting of the tube bundle and reduced scaling. This means less downtime for cleaning and reduced blowdown for less water waste.

VC Distillation Process Flow Diagram


Vapor Compression Distillation

Pharma Standard Units

Model Distillate Output (GPH) Width (in) Length (in) Height (in)
PR300 300 72 138 79
PR600 600 72 138 79
PR800 800 87 188 85
PR1000 1000 87 188 85
PR1200 1200 87 188 85
PR1500 1600 100 226 106
PR3000 3000 138 225 129
PR4500 4500 140 254 130
PR6000 6000 147 298 156
PR7200 7200 147 298 156
PR9000 9000 151 337 160


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